Department of Chemistry,
Division of Mathematical,
Life, and Physical Sciences,
Physical Sciences
North 1631;
Telephone (805)
893-2931
Department Chair: R. Daniel Little
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Curtis B. Anderson, Ph.D., UC Los Angeles, Associate Professor (organic chemistry)
Donald H. Aue, Ph.D., Cornell University, Associate Professor (organic chemistry)
Michael T. Bowers, Ph.D., University of Illinois, Professor (physical chemistry)
Paula Yurkanis Bruice, Ph.D., University of Virginia, Senior Lecturer with Security of Employment (bio-organic chemistry)
Thomas C. Bruice, Ph.D., University of Southern California, Research Professor
Clifford A. Bunton, Ph.D., University College (London), Professor Emeritus
Steven Buratto, Ph.D., California Institute of Technology, Assistant Professor (physical chemistry)
Alison Butler, Ph.D., UC San Diego, Professor (bio-inorganic chemistry)
Anthony Cheetham, Ph.D., Oxford University, Professor (inorganic chemistry/materials)
Timothy J. Deming, Ph.D., UC Berkeley, Assistant Professor (organic chemistry)
Peter C. Ford, Ph.D., Yale University, Professor (inorganic chemistry)
J. Thomas C. Gerig, Ph.D., Brown University, Professor (bio-organic chemistry)
David O. Harris, Ph.D., UC Berkeley, Professor (physical chemistry)
Thomas M. Hooker, Jr., Ph.D., Duke University, Professor (biophysical chemistry)
William C. Kaska, Ph.D., University of Michigan, Professor (inorganic chemistry)
John H. Kennedy, Ph.D., Harvard University, Professor Emeritus
Bernard Kirtman, Ph.D., Harvard University, Professor (theoretical physical chemistry)
Lori A. Kohlstaedt, Ph.D., UC Berkeley, Assistant Professor (biochemistry)
Sandra I. Lamb, Ph.D., UC Los Angeles, Academic Coordinator (physical organic chemistry)
Bruce H. Lipshutz, Ph.D., Yale University, Professor (organic chemistry)
R. Daniel Little, Ph.D., University of Wisconsin, Professor (organic chemistry)
Richard M. Martin, Ph.D., University of Wisconsin, Professor Emeritus
Horia I. Metiu, Ph.D., Massachusetts Institute of Technology, Professor (theoretical physical chemistry)
William E. Palke, Ph.D., Harvard University, Professor (theoretical physical chemistry)
Stanley M. Parsons, Ph.D., California Institute of Technology, Professor (biological chemistry)
Ralph G. Pearson, Ph.D., Northwestern University, Professor Emeritus
John Perona, Ph.D., Yale University, Assistant Professor (biological chemistry)
Glyn O. Pritchard, Ph.D., Manchester University, Professor Emeritus
Norbert O. Reich, Ph.D., UC San Francisco, Associate Professor (biological chemistry)
Bruce Rickborn, Ph.D., UC Los Angeles, Professor (organic chemistry)
Seung Koo Shin, Ph.D., California Institute of Technology, Assistant Professor (physical chemistry)
Galen Stucky, Ph.D., Iowa State University, Professor (inorganic chemistry)
Richard J. Watts, Ph.D., University of Colorado, Professor (inorganic chemistry)
Alec M. Wodtke, Ph.D., UC Berkeley, Professor (physical chemistry)
The major in chemistry provides excellent undergraduate preparation for careers in chemical research, teaching, medicine, law, technical management, and environmental fields. The Department of Chemistry offers programs leading to either the B.S. or the B.A. degree. The requirements of the B.A. program do not meet standards for certification by the American Chemical Society, but three additional courses may be taken to meet certification standards (see below). The requirements of the B.S. program meet American Chemical Society standards for certification without modification. The B.S. degree is intended for students interested in a career whose primary focus is chemistry or a chemistry-related science, including medicine, biochemistry, and materials science as well as graduate work in chemistry.
The B.A. degree offers flexibility and is intended for students interested in a career with a significant chemical-related component such as environmental science, law, K-12 education, or business. Students should discuss these options with an advisor in the department.
Entering chemistry majors will be assigned an advisor who may be consulted on any matter pertaining to departmental activities, including waivers and substitutions of major requirements. Students must submit their programs to the advisor for approval.
Students with a bachelor's degree in chemistry who are interested in pursuing a California Teaching Credential should contact the credential advisor in the Graduate School of Education as soon as possible.
Upper-division major. Fifty-four upper-division units, including Chemistry 130A-B-C, 113A-B-C, 114A-B, 150, 150L, and 173A-B, are required. With approval of the junior or senior advisor, Chemistry 107A-B, 108 may be substituted for Chemistry 130A-B-C, but Chemistry 131A and one other upper-division course worth at least 3 units must be completed when this substitution is made. Chemistry 131A and the other upper-division course used to fulfill this added requirement shall not be included among the 12 upper-division elective units required for the B.S. degree. B.S. students who take Chemistry 107A-B, 108 cannot take Chemistry 130A-B-C for degree credit following completion of 107A-B, 108. The remaining 12 major units will normally include two physical chemistry courses, one organic or biological chemistry course, and one upper-division laboratory course. Courses should be chosen after consultation with the junior or senior advisor. It is strongly recommended that Chemistry 173A be taken before Chemistry 173B. Transfer students who receive subject credit for Chemistry 130 and/or 150 must earn at least 44 upper-division units in chemistry. Completion of sufficient units of Chemistry 7B-C or Chemistry CS 7 will be considered equivalent to Chemistry 136 and Chemistry 136L and can be used to fulfill the upper-division chemistry laboratory requirement for the B.S. degree.
Upper-division major. Thirty-nine to 40 upper-division units, including Chemistry 130A-B-C, 113A-B-C, 114A or B, 150, 150L, 173A or B. One chemistry elective (at least 3 units and not 199) is required to complete the major. With approval of the junior or senior advisor, Chemistry 107A-107B-108 may be substituted for Chemistry 130A-B-C, but an additional upper-division course worth at least 3 units must be taken. This course must be approved for the student's specific plan of study by that advisor. B.A. students who take Chemistry 107A-B, 108 cannot take Chemistry 130A-B-C for degree credit following completion of 107A-B, 108.
Students should consult an advisor in the Department of Chemistry regarding possible substitutions. Transfer students who receive subject credit for Chemistry 130 and/or 150 because they completed equivalent lower-division courses elsewhere must earn at least 36 upper-division units in chemistry.
The B.A. degree in chemistry will meet the standards recommended by the American Chemical Society (ACS) for professional education in chemistry provided the student completes three additional courses in chemistry, including two laboratory courses (Chemistry 6C may be used for partial fulfillment of this requirement). Students should consult the senior advisor in regard to ACS certified degrees.
Department of Chemistry requirements for the program include Chemistry 1A-B-C, 1AL-BL-CL, 6A-B-C, 130A-B-C, 150, 150L, 113B-C, 114A or B, 173A or B, and two additional upper-division courses in chemistry. Mathematics 3A-B-C, 5A-B-C, Physics 1 (or Mechanical Engineering 10), and Physics 3, 4, 3L, 4L are also required.
Interested students may obtain more information about the program from the Department of Chemistry or the Department of Chemical Engineering. Final admission to the program is subject to the approval of the dean or provost of each college.
Preparation for the minor. No specific courses are required for the minor in chemistry, but students should note that most upper-division chemistry courses include Chemistry 1A-B-C as prerequisite, and many require mathematics courses through 5A as prerequisite.
Upper-division minor. Twenty upper-division units, including at least one course (4 units) in physical chemistry (Chemistry 113A or 113B or 113C); and 16 units of additional upper-division chemistry courses (Chemistry 101 may not apply).
Note: Substitutions and waivers are subject to approval by the chair of the department. Please see the section on Academic Minors for special conditions governing minors in the College of Letters and Science.
The M.S., M.A., or Ph.D. degrees in chemistry may be obtained in any one of the special fields of analytical, biological, inorganic, organic, physical, or theoretical chemistry. In addition to departmental requirements, candidates for graduate degrees must meet university degree requirements found in the chapter "Graduate Education at UCSB." The Graduate Record Examination (GRE) is required of all applicants to the graduate program. Applicants whose native language is not English must receive a score of at least 550 on the Test of English as a Foreign Language (TOEFL), taken within two years of their application to UCSB. Students who have earned a bachelor's or master's degree from a U.S. college or university are exempt from this requirement. Graduate Study in Chemistry, a publication containing admission and degree requirements, is available upon request from the Department of Chemistry.
Applications are accepted all year long for fall, winter, and spring quarters. However, January 15, is the priority deadline for fall applications and for campuswide fellowship competition.
A six-course curriculum is established with and approved by the divisional academic advisor and normally completed during the first year. Several additional elective courses will be taken during the first and second year. The two preliminary evaluations include written examinations, propositions, and cumulative examinations, depending on the division. All requirements and the seminar presentation must be completed before the Ph.D. oral qualifying examination. The Ph.D. qualifying oral examination, which focuses on the student's dissertation research field, is usually scheduled for the end of the sixth quarter.
Ph.D. candidates will prepare and defend a dissertation detailing an original work of research in their field of specialization.
1AL-BL-CL. General
Chemistry Laboratory
(1-1-1) Staff
Prerequisite: concurrent
registration in Chemistry 1A-B-C or consent of instructor. Laboratory,
4 hours. A lab fee may be required.
Quantitative measurements
demonstrating principles and developing laboratory technique. Inorganic
qualitative analysis. Inorganic synthesis.
2A. General Chemistry
(Honors)
(3) Staff
Prerequisites:
one year of high-school chemistry or physics, one quarter of calculus (may
be taken concurrently), and consent of instructor. Lecture, 3 hours.
Enrollment will be
limited to 40 students. The sequence of topics will be similar to that
in Chemistry 1A. Calculus will be used as needed, at the level of the concurrent
Mathematics 3A course.
2AL. General Chemistry
Laboratory (Honors)
(1) Staff
Prerequisite: concurrent
registration in Chemistry 2A. Laboratory, 3 hours. A lab fee may be required.
Quantitative measurements
demonstrating principles and developing laboratory technique.
2B. General Chemistry
(Honors)
(3) Staff
Prerequisites:
Chemistry 1A and consent of instructor. Lecture, 3 hours.
Thermodynamics, reaction
kinetics, thermochemistry, oxidation and reduction, electrochemistry, chemical
equilibrium. Laboratory required.
2BL. General Chemistry
Laboratory (Honors)
(1) Staff
Prerequisites:
Chemistry 1A-AL. (3.0 grade-point average or consent of instructor.) Laboratory,
3 hours. A lab fee may be required.
Laboratory techniques.
Thermodynamics, reaction kinetics, thermochemistry, oxidation and reduction,
electrochemistry, chemical equilibrium.
2C. General Chemistry
(Honors)
(3) Staff
Prerequisites:
Chemistry 1A-B, or Chemistry 1A, 2B. Consent of instructor. Lecture, 2
hours.
Structure and dynamics
of the elements and their compounds. Aspects of technology and environmental
problems. Laboratory required.
2CL. General Chemistry
Laboratory (Honors)
(1) Staff
Prerequisites:
Chemistry 1B, 2BL. Laboratory, 3 hours. A lab fee may be required.
Laboratory techniques.
Structure and dynamics of the elements and their compounds. Aspects of
technology and environmental problems.
6A-B-C. Laboratory
Methods of Organic Chemistry
(2-2-2) Staff
Prerequisites:
concurrent enrollment in Chemistry 130A-B-C, or 107A-B and 108. If student
begins 107A in fall and needs only two quarters of laboratory, 6A-B may
be postponed to winter and spring. A lab fee may be required.
Distillation, crystallization,
extraction, determination of physical properties, organic synthesis, instrumental
methods in organic chemistry.
7B-C. Laboratory
Methods of Organic Chemistry (Honors)
(2-2) Staff
Prerequisites:
Chemistry 6A and consent of instructor. Laboratory, 8 hours. A lab fee
may be required.
Topics will be similar
to those in Chemistry 6B-C, but with more flexible laboratory hours and
more emphasis on instrumental analysis and spectroscopy for the characterization
of organic compounds in conjunction with the Chemistry CS 7 course in the
College of Creative Studies.
25. Introductory
Chemistry
(3) Staff
Not open to students
who have completed Natural Science 1B. This course is designed to meet
the non-science majors' General Education requirement in the physical sciences.
The course may also serve as background preparation for Chemistry 1A. Lecture,
3 hours.
The course includes
such basic topics as atomic theory, weight relations, nomenclature, chemical
bonding, kinetic molecular theory, gas laws, solutions, and related areas
of modern chemistry.
90FS. Freshman Seminar
(2) Staff
Seminar, 2 hours.
Informal discussion
limited to 10 students in each section. Each participating faculty member
will conduct one section. Subjects will include current technological and
environmental problems, and recent advances in basic and applied chemistry.
91. Undergraduate
Seminar
(1) Staff
Prerequisites:
Chemistry 1A-B or concurrent enrollment. May be repeated once for credit.
Seminar, 1 hour.
Seminars for undergraduates
presented by faculty and/or students.
94. Group Studies
in Chemistry
(1) Harris
Prerequisite: consent
of instructor. May be repeated for credit to a maximum of 3 units.
Lecture and discussions
on special topics.
99. Introduction
to Research
(1-3) Staff
Prerequisites:
consent of instructor and undergraduate advisor. May be repeated to a maximum
of 6 units. Students are limited to 5 units per quarter and 30 units total
in all 98/99/198/199/199RA courses combined. Tutorial, 3-9 hours.
Directed study, normally
experimental, to be arranged with individual faculty members. Course offers
exceptional students an opportunity to participate in a research group.
The student will learn basic techniques and the operation of instruments
used in research. Each faculty member has a unique number designation.
107A-B. Fundamentals
of Organic Chemistry
(3-3) P. Bruice
Prerequisites:
Chemistry 1A-B-C. Chemistry 107A not open to credit to students who have
completed Chemistry 8A or 130A; Chemistry 107B not open for credit to students
who have completed Chemistry 8B or 130B.
Structure and reactivity
of organic compounds including nomenclature, isomerism, spectroscopy, catalysis,
reaction mechanisms and stereochemistry.
108. Fundamentals
of Organic Chemistry
(4) P. Bruice
Prerequisites:
Chemistry 1A-B-C, 107A, 107B. Not open for credit to students who have
completed Chemistry 8C or 130C.
Application of the
principles of organic chemistry to biochemical systems: carbohydrates,
proteins, enzymes, vitamins and cofactors. Designed primarily for biological
science majors.
112. Biophysical
Chemistry
(4) Staff
Prerequisite: Chemistry
113A.
Thermodynamics, kinetics,
and quantum chemistry with special emphasis on biological systems. Some
examples of special emphasis: diffusion across and within membranes, diffusion
along DNA, phase equilibria and protein folding, spectroscopy (fluorescence,
mass spectroscopy, FTIR, NMR), electron transfer and hydrogen bonding.
112L. Biophysical
and Bioanalytical Laboratory
(3) Staff
Prerequisite: Chemistry
113A.
Introduction to the
use of modern biophysical techniques. Fluorescence spectroscopy, mass spectroscopy,
FTIR, NMR, diffraction techniques, etc. Emphasis is on quantitative analysis.
113A-B-C. Physical
Chemistry
(4-4-4) Bowers,
Harris, Metiu, Palke
Prerequisites:
Chemistry 1A-B-C; Mathematics 3A-B-C; and Physics 1, 2, 3, 4, 3L, 4L or
6A-B-C and 6AL-BL-CL; or by consent of instructor. Lecture, 3 hours; discussion,
1 hour.
A. Chemical thermodynamics:
laws of thermodynamics, phase equilibria, chemical equilibria, equations
of state.
B. Quantum theory
and spectroscopy: introduction to quantum mechanics; symmetry, molecular
structure, and spectroscopy.
C. Kinetic theory
of gases, chemical kinetics, statistical mechanics, photochemistry.
113AG-BG-CG. Physical
Chemistry
(4-4-4) Bowers,
Harris, Metiu, Palke
Open only by consent
of the chemistry graduate advisor to graduate students who have not taken
Chemistry 113A-B-C or the respective part thereof at this institution.
Lecture, 3 hours; discussion, 1 hour.
114A-B. Physical
Chemistry Laboratory
(3-3) Bowers, Shin
Prerequisites:
Chemistry 150 and 150L or equivalent; Chemistry 113A concurrently with
Chemistry 113B. Lecture, 1 hour; laboratory, 8 hours. A lab fee may be
required.
Lecture: treatment
of experimental data, error analysis, instrumental data acquisition techniques,
special topics. Laboratory: experiments and reports involving physical
properties of gases, thermochemistry, solutions, phase equilibria, chemical
kinetics, surface phenomena, molecular electric and magnetic properties,
molecular spectra and structure, properties of solids, and computer data
analysis.
115A-B-C. Fundamentals
of Quantum Chemistry
(3-3-3) Kirtman,
Palke, Wodtke
Prerequisites:
Chemistry 113A-B-C, Mathematics 5A or consent of instructor. Lecture, 3
hours.
A. Introduction to
quantum mechanics-postulatory approach; particle in box, on ring, harmonic
oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation
theory, variation theory; applications.
B. Molecular orbital
theory and valence bond theory; Huckel theory (secular eqn.) applications
to conjugated systems. Electronic spectra, and term symbols; introduction
to infrared, Raman, and microwave spectroscopy.
C. Introduction to
NMR, EPR, group theory; applications.
115AG-BG-CG. Fundamentals
of Quantum Chemistry
(3-3-3) Kirtman,
Palke, Wootke
Open only by consent
of the chemistry graduate advisor to graduate students who have not taken
Chemistry 115A-B-C at this institution. Lecture, 3 hours.
117. Statistical
Thermodynamics
(3) Metiu, Palke,
Wootke
Prerequisites:
Chemistry 113A-B-C or consent of instructor. Lecture, 3 hours.
Fundamentals of statistical
thermodynamics, partition functions for ideal gases and crystals, quantum
statistics, calculations of thermodynamic properties.
117G. Statistical
Thermodynamics
(3) Metiu, Palke,
Wootke
Open only by consent
of the chemistry graduate advisor to graduate students who have not taken
Chemistry 117 at this institution. Lecture, 3 hours.
118. Photochemistry
and Radiation Chemistry
(3) Staff
Prerequisite: Chemistry
113B. Lecture, 3 hours.
Interaction of light
and matter, reaction paths from electronically excited molecules, flash
photolysis, high energy radiation.
120. Polymer Chemistry
(3) Staff
Prerequisite: Chemistry
130A-B-C.
Mechanism and kinetics
of polymerization: vinyl, condensation, and diene polymers; ionic polymerizations;
block and graft polymers; copolymerization; physical chemistry of high
polymers; polymer degrations; radiation chemistry of polymer systems.
123. Fundamentals
of Environmental Chemistry
(3) Staff
Prerequisites:
Chemistry 1A-B and either Chemistry 1C, 8A (or 130A) or Environmental Studies
115.
Chemical nature of
pollution sources. Principles of analytical monitoring and control of pollution
sources. The chemistry of pollutants in the environment. Chemical quality
standards and chemical monitoring of the environment.
125L. Laboratory
Techniques in Biochemistry
(4) Staff
Prerequisites:
Chemistry 142A-B.
Protein chemistry
(e.g., double labeling radioisotope analysis, two dimensional PAGE, ELISA,
HPLC, FPLC, LC-electrospray mass spectrometry, NMR, and EPR), nucleic acid
chemistry (e.g., chemical DNA synthesis, DNA sequencing, PCR-based selection),
and enzyme kinetics (e.g., inhibition analyses, coupled enzyme assays).
130A-B-C. Organic
Chemistry
(4-4-4) Staff
Prerequisites:
Chemistry 1A-B-C or consent of instructor. Concurrent enrollment in Chemistry
6A-B-C. Not open for credit to students who have completed Chemistry 107A-B
and 108.
Structure, reactivity,
mechanisms, synthesis, nomenclature, and spectroscopic identification of
the principal classes of organic compounds as well as organometallics,
amino acids, proteins, and carbohydrates. This course is intended for chemistry
majors and others requiring a strong basis in organic chemistry (see majors
in biochemistry-molecular biology, chemical engineering, pharmacology,
physiology, and cell biology).
130AG-BG-CG. Organic
Chemistry
(4-4-4) Staff
Open only by consent
of the chemistry graduate advisor to graduate students who have not taken
Chemistry 130A-B-C at this institution. Lecture, 3 hours.
131A-B-C. Advanced
Organic Chemistry
(3-3-3) Anderson,
Rickborn, Little, Aue, Lipshutz
Prerequisites:
Chemistry 130A-B-C or consent of instructor. Lecture, 3 hours.
A. Physical organic
chemistry, mechanism, stereochemistry, structure, and reactivity.
B and C. Mechanism
and synthesis in organic chemistry.
136. Qualitative
Organic Analysis
(2) Aue, Little,
Rickborn
Prerequisites:
Chemistry 130A-B-C and Chemistry 6A-B-C, or consent of instructor. Lecture,
2 hours.
Identification of
unknown organic compounds; separation of mixtures; derivatives, instrumental
methods; microtechniques.
136L. Qualitative
Organic Analysis Laboratory
(2) Aue, Little,
Rickborn
Prerequisite: concurrent
enrollment in Chemistry 136. Laboratory, 8 hours. A lab fee may be required.
140. Synthetic Methods
in Chemistry
(3) Staff
Prerequisites:
Chemistry 6A-B-C, 150, and 150L. May be repeated for credit to a maximum
of 6 units. A lab fee may be required.
Synthesis and characterization
of inorganic, organic, organometallic, polymeric, and bio-materials. Designed
to fulfill the department's requirements for the BS degree with American
Chemical Society certification. Focus to be placed on advanced laboratory
techniques used in a research setting.
142A-B-C. Chemical
Aspects of Biological Systems
(3-3-3) Parsons,
Reich
Prerequisite: Chemistry
130C or consent of instructor. Lecture, 3 hours.
A. Macromolecules
of biological importance. A survey of the physical and chemical properties
of proteins, nucleic acids, and carbohydrates. Methods of preparation,
chemical synthesis, degradation, and characterization of bio-molecules.
B. Chemical aspects
of intermediary metabolism. The chemistry and elementary dynamic properties
of enzymes; study of enzyme active sites; characterization of metabolic
pathways and methods of examining cellular regulation.
C. Macromolecular
biosynthesis and specialized cellular processes. A survey of nucleic acid
and protein biosynthesis, characterization of lipids and membranes; function
of membranes in transport, energy transduction, and cellular control; mechanisms
of muscle contraction and cell motility.
145. Computational
Biochemistry
(3) Kohlstaedt,
Perona, Reich
Prerequisites:
Chemistry 112, 113A or Chemistry 113B-C, Chemistry 142A-B-C; or MCDB 108A-B-C;
or consent of instructor.
Introduction to molecular
modeling and molecular dynamics. Discussion of practical considerations
of energy minimization, solvent modeling, structure-based drug design.
Practical computer graphics experience.
146. Membrane Biochemistry
(3) Parsons, Reich
Prerequisites:
Chemistry 142A-B-C; or MCDB 108A-B-C; or consent of instructor.
Introduction to the
structures and roles of lipids and their phase behavior, liposomes, membrane
proteins and kinetics, protein sorting, and signal transduction.
150. Analytical
Chemistry
(3) Staff
Prerequisites:
Chemistry 1A-B-C or consent of instructor. Lecture, 3 hours.
Principles of analytical
chemistry including classical techniques, spectrophotochemistry, electroanalytical
techniques, and separation processes.
150L. Analytical
Chemistry Laboratory
(3) Staff
Prerequisite: concurrent
enrollment in Chemistry 150 or consent of instructor. Laboratory, 8 hours.
A lab fee may be required.
Students will perform
experiments in several areas of analytical chemistry including gravimetric,
volumetric, electroanalytical, spectrophotometric, and separation techniques.
Analyses of water, blood, consumer products, and industrial alloys are
carried out.
153. Advanced Analytical
Techniques
(3) Staff
Prerequisite: Chemistry
150 or consent of instructor. Lecture, 2 hours; laboratory, 4 hours.
A lab fee may be
required.
Principles of analytical
methodology, as in spectroscopy, electronanalysis, and chromatography.
Applications to environmental problems, forensic and clinical analysis,
and industry. Analysis of solids and surfaces.
161. Enzyme Mechanisms
(3) Staff
Prerequisites:
Chemistry 142A-B-C; or MCDB 108A-B-C; or consent of instructor.
Chemistry, structure
and function of enzymes; theory, experimental design, and data analysis.
Enzyme models and non-classical enzymes.
162. Drug Design
(3) Reich
Prerequisites:
Chemistry 142A-B-C; or MCDB 108A-B-C; or consent of instructor.
Rational drug design.
Active site-directed and mechanism-based inhibitors. The use of computers
and energy calculations on the design of drugs. Structure based drug design.
171. Bioinorganic
Chemistry
(3) Staff
Prerequisite: Chemistry
173A or consent of instructor.
Selected topics in
bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins
and corresponding model compound investigations. Emphasis will be on reactions
mechanisms and spectroscopy or properties of metal sites.
173A. Advanced Inorganic
Chemistry
(3) Staff
Prerequisites:
Chemistry 113A-B-C or consent of instructor. Lecture, 3 hours.
Electronic structure
of atoms and molecules. Models for bonding in molecules of nontransition
and transition elements. Applications of symmetry to bonding, electronic
and vibrational spectroscopy. Stereochemistry of transition metal complexes
and introduction to organometallics.
173B. Advanced Inorganic
Chemistry
(3) Staff
Prerequisites:
Chemistry 113A-B-C and 173A, or consent of instructor. Lecture, 3 hours.
Structures of ordered
crystalline solids, X-ray crystallography. Introduction to solid state
chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
174. Advanced Inorganic
Synthesis and Laboratory Techniques
(3) Kaska
Prerequisite: Chemistry
173 (may be taken concurrently) or consent of instructor. Lecture, 1 hour;
laboratory, 8 hours. A lab fee may be required.
Methods of inorganic
synthesis such as the synthesis of transition metal complexes, organometallics,
and bioinorganic compounds. Spectroscopic characterization of compounds.
175. Physical-Inorganic
Chemistry
(3) Ford, Watts
Prerequisites:
Chemistry 173A-B or consent of instructor. Lecture, 3 hours.
Bonding theory, thermodynamics,
and structure of inorganic compounds. Applications of physical techniques
to the study of inorganic (and organometallic) reactions and their mechanisms.
176. Inorganic Chemistry
of Solar Energy Conversion
(3) Ford, Watts
Prerequisites:
Chemistry 113A-B. Lecture, 3 hours.
Survey of applications
of basic principles of physical chemistry, photochemistry, and electrochemistry
to solar energy conversion processes. Selected systems designed to convert
solar energy to chemical fuel, electricity, and heat will be treated in
detail during the survey.
176G. Inorganic
Chemistry of Solar Energy Conversion
(3) Ford, Watts
Prerequisites:
Chemistry 113A-B. Lecture, 3 hours.
Survey of applications
of basic principles of physical chemistry, photochemistry, and electrochemistry
to solar energy conversion processes. Selected systems designed to convert
solar energy to chemical fuel, electricity, and heat will be treated in
detail during the survey.
181. Protein Crystallography
(3) Kohlstaedt,
Perona
Prerequisite: consent
of instructor.
Introduction to diffraction
techniques. Protein crystal growth and morphology. Data collection and
reduction strategies. Approaches for solving the phase problem. Crystallographic
refinement, including molecular dynamics. Interpretation of crystal structure.
184. Chemical Literature
(2) Huber
Prerequisites:
12 units of Chemistry. Lecture, 2 hours.
Lectures and exercises
on the literature and other information resources of use in chemistry.
195. Chemical Instrumentation
(3-5) Staff
Prerequisites:
consent of instructor and undergraduate advisor. Discussion, 1 hour; laboratory,
6 to 12 hours.
With guidance from
a faculty member students learn advanced laboratory techniques by independent
experimental work and weekly consultations with the instructor. This course
may be used to satisfy the upper-division laboratory requirement.
196. Special Courses
(1-4) Staff
Prerequisite: consent
of instructor and undergraduate advisor. Tutorial, 3-12 hours.
Special courses as
a means of meeting special curriculum needs.
197. Senior Thesis
Project
(1-4) Staff
Prerequisites:
consent of instructor. Must have a grade-point average in the major of
3.25 or higher.
Academic research
supervised by a faculty member, and resulting in a written thesis document.
199. Independent
Studies in Chemistry
(1-5) Staff
Prerequisites:
students must (1) have attained upper-division standing in the major; (2)
have a minimum 3.0 grade-point average for the preceding three quarters;
(3) have completed at least two upper-division courses in chemistry. Students
are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199RA
courses combined. Not applicable to the B.A. in Chemistry. No more than
12 units of Chemistry 199 may apply toward the B.S. in Chemistry. Consent
of department and instructor. Tutorial, 1-5 hours.
Coursework shall consist
of academic research supervised by a faculty member. This course is not
intended for internship credit.
211. Chemical Kinetics
(3) Staff
Prerequisite: consent
of instructor. Lecture, 3 hours.
A course in the laws
and theories governing rates of chemical reactions and reaction mechanisms.
Empirical treatment of reaction rates, treatment of data, gas-phase reactions,
reactions in solution, catalysis, complex reactions, chain reactions. Collision
theory and potential energy surfaces.
212. Chemical Dynamics
(3) Staff
Prerequisite: consent
of instructor. Lecture, 3 hours.
Dynamics of molecular
collisions and elementary chemical reactions, including elastic and inelastic
collisions, potential energy surfaces, reactive scattering, state specific
reaction cross sections, reagent state preparation and product state analysis,
molecular beam and laser techniques in chemical dynamics. (Normally offered
in alternate years.)
214A-B. Statistical
Mechanics
(3-3) Metiu
Prerequisite: consent
of instructor. Course content changes and the course may be repeated with
a different topic (18 units maximum). Lecture, 3 hours.
Selected topics in
advanced statistical mechanics. Critical phenomena and renormalization
group theory. Correlation functions and response functions with applications
to light, electron, neutron, and atom scattering from solids to liquids.
Time dependent statistical mechanics with applications to relaxation phenomena.
Stochastic methods.
215A-B. Quantum
Mechanics
(3-3) Metiu, Palke
Prerequisite: consent
of instructor. Course content changes each year and may be repeated with
a different topic (18 units maximum). Lecture, 3 hours.
Selected topics in
advanced quantum mechanics. Scattering theory with applications to potential
scattering, electron scattering, and chemical reactions. Quantum theory
of light and its interaction with matter. Molecular spectroscopy. Electronic
structure calculations.
216A-B-C. Fundamentals
of Quantum Chemistry
(3-3-3) Kirtman,
Palke
Prerequisite: consent
of the chemistry graduate advisor.
A. Introduction to
Quantum Mechanics-Postulatory Approach; particle in box, on ring, harmonic
oscillator, linear operator theory, matrix algebra; hydrogen atom; perturbation
theory, variation theory applications.
B. Molecular orbital
theory and valence bond theory, Huckel theory (secular equn.) applications
to conjugated systems, electronic spectra, and term symbols introduction
to infrared, Raman and microwave spectroscopy.
C. Introduction to
NMR, EPR, Group Theory; applications.
217. Statistical
Thermodynamics
(3) Metiu, Palke
Prerequisite: consent
of the chemistry graduate advisor.
Fundamentals of statistical
thermodynamics, partition functions for ideal gases and crystals, quantum
statistics, calculations of thermodynamic properties.
218. Photochemistry
and Radiation Chemistry
(3) Staff
Prerequisite: consent
of the chemistry graduate advisor.
Interaction of light
and matter, reaction paths from electronically excited molecules, flash
photolysis, high energy radiation.
219. Selected Topics
in Physical Chemistry
(1-4) Staff
Prerequisite: consent
of instructor. Course may be repeated with a different topic (18 units
maximum). Lecture, 1 to 4 hours.
Selected topics: orbital
symmetry rules for chemical reactions (Pearson); classical theory of light,
radiation, and spectroscopy (Metiu); nonlinear optics and nonlinear spectroscopy
(Metiu).
220. Surface Chemical
Physics
(3) Staff
Prerequisite: consent
of instructor. Lecture, 3 hours.
Interactions of molecules
with surfaces with emphasis on energy transfer. Condensation/evaporation,
dissociation, internal energy transfer. Surface bonding and surface catalysis.
Includes discussion of important surface instrumentation methods.
221. Transitions
Metal Catalyed Polymerization
(3) Deming
Prerequisite: consent
of instructor. Same course as Materials 282. Lecture, 3 hours.
Examination of strategies
for controlling molecular weight, chain distribution, sequence, endgroups,
and stereochemistry. Discussion of the influence of these variables over
structure and properties. Tacticity, control, Ziegler-Natta catalysis,
living polymerizations, stereoselective and enantioselective polymerizations,
secondary and tertiary structures, polymer assemblies, and biological polymerization.
225. Instrumental
Methods in Physical Chemistry
(3) Staff
Prerequisite: consent
of instructor. Advanced undergraduates may enroll by petition to their
college office. Lecture, 3 hours.
Fundamentals of basic
measurements and advanced research instrumentation are taught. Emphasis
is on both practical and conceptual understanding of the methods, suitable
for experimental design. Signal electronics, vacuum techniques, molecular
beams, lasers, and optics.
230. Modern Instrumental
Techniques in Organic Chemistry
(3) Staff
Prerequisite: graduate
standing or consent of instructor. Lecture, 3 hours.
Practical spectroscopy
including infrared and ultraviolet, but with primary emphasis on nuclear
magnetic resonance, electron spin resonance, and mass spectroscopy. (Not
offered every year.)
231A-B-C. Advanced
Organic Chemistry
(3-3-3) Anderson,
Aue, Lipshutz, Little, Rickborn
Prerequisite: consent
of the chemistry graduate advisor. Not open for credit to students who
have completed Chemistry 226A-B-C.
A. Physical organic
chemistry-mechanism, stereochemistry, structure and reactivity.
B and C. Mechanism
and synthesis in organic chemistry.
233. Advanced Synthetic
Chemistry
(3) Aue, Lipshutz,
Rickborn
Prerequisite: consent
of instructor. Lecture, 3 hours.
A comprehensive discussion
of modern synthetic organic methods, including the applications of addition,
condensation, substitution, and rearrangement reactions. (Not offered every
year.)
236. Molecular Orbital
Theory
(3) Staff
Prerequisite: graduate
standing or consent of instructor. Lecture, 3 hours.
Applications of molecular
orbital theory to organic chemistry. (Not offered every year.)
237. Advanced Physical
Organic Chemistry
(3) Staff
Prerequisite: consent
of instructor. Not open for credit to students who have completed Chemistry
231. Lecture, 3 hours.
Study of the structural
and environmental factors which influence the course of chemical reactions
of organic compounds.
239. Selected Topics
in Organic Chemistry
(1-4) Staff
Prerequisite: consent
of instructor. Course may be repeated with a different topic (18 units
maximum). Lecture, 3 hours.
Selected topics in
organic chemistry. The contents of this course will vary.
242A-B-C. Chemical
Aspects of Biological Systems
(3) Parsons, Reich
Prerequisite: consent
of the chemistry graduate advisor.
A. Macromolecules
of biological importance. A survey of the physical and chemical properties
of proteins, nucleic acids, and carbohydrates. Methods of preparation,
chemical synthesis, degradation, and characterization of biomolecules.
B. Chemical aspects
of intermediary metabolism. The chemistry and elementary dynamic properties
of enzymes; study of enzyme active sites; characterization of metabolic
pathways and methods of examining cellular regulation.
C. Macromolecular
biosynthesis and specialized cellular processes. A survey of nucleic acid
and protein biosynthesis, characterization of lipids and membranes; function
of membranes in transport, energy transduction, and cellular control; mechanisms
of muscle contraction and cell motility; neurochemistry.
245. Computational
Biochemistry
(3) Kohlstaedt,
Perona, Reich
Prerequisites:
Chemistry 113A; 112; 142A-B-C or Chemistry 113A-B-C. Same course as Biochemistry-Molecular
Biology 245.
Introduction to molecular
modeling and molecular dynamics. Discussion of practical considerations
of energy minimization, solvent modeling, structure-based drug design.
Practical computer graphics experience.
246. Membrane Biochemistry
(3) Parsons, Reich
Prerequisites:
Chemistry 142A-B-C or consent of instructor. Same course as Biochemistry-Molecular
Biology 246.
Introduction to the
structures and roles of lipids and their behavior, lipsomes, membrane proteins
and kinetics, protein sorting, and signal transduction.
250. Seminar in
Biological Chemistry
(2) Staff
Prerequisite: consent
of instructor. May be substituted for Chemistry 290 requirement. Lecture,
2 hours.
Presentation of seminar
in the areas of biophysical, bio-organic, or biological chemistry.
253. Advanced Analytical
Techniques
(3) Staff
Prerequisites:
open only by consent of the Chemistry Graduate Advisor.
Principles of analytical
methodology, as in spectroscopy, electroanalysis and chromatography. Applications
to environmental problems, forensic and clinical analysis, and industry.
The laboratory will require the analysis of an environmental sample by
two or more methods.
254A-B. Magnetic
Resonance Techniques in Biological Systems
(3-3) Gerig
Prerequisite: consent
of instructor. Lecture, 3 hours.
A discussion of the
theory and practice of magnetic resonance methods currently used in studies
of proteins, nucleic acids, and polysaccharides both individually and in
complex structures such as membranes. NMR and EPR techniques will be included
but the emphasis will be on high-resolution 1H and 13C spectroscopy. (Normally
offered in alternate years.)
255A-B-C. Methods
in the Characterization of Biological Macromolecules
(3-3-3) Gerig,
Hooker
Prerequisites:
physical chemistry, biochemistry, calculus, or consent of instructor. Lecture,
2 hours; discussion, 1 hour.
A. Introduction to
biophysical chemistry. Macromolecular structure and conformation, intermolecular
interactions, and multiple equilibria.
B. Theory and practice
of physical methods employed to study macromolecules. Spectroscopic techniques,
including ORD, CD, UV, fluorescence and phosphorescence, NMR, and ESR.
C. Theory and practice
of physical methods employed to study macromolecules. Hydrodynamic properties,
including sedimentation, diffusion, viscosity, osmotic pressure.
256A. Physical Biochemistry
(5) Staff
Prerequisites:
one year of undergraduate courses in each of the following: biochemistry,
organic chemistry, physical chemistry, or consent of instructor. Same course
as Biochemistry-Molecular Biology 256A. Lecture, 4-5 hours.
Isolation and structural
analysis of biomolecules. Hydrodynamics and spectroscopics.
256B. Enzyme Kinetics
and Mechanisms
(5) Staff
Prerequisites:
one year of undergraduate courses in each of the following: biochemistry,
organic chemistry, physical chemistry, or consent of instructor. Same course
as Biochemistry-Molecular Biology 256B. Lecture, 4-5 hours.
Enzyme kinetic and
chemical mechanisms. Theory, experimental design, and data analysis. Enzyme
models and non-classical enzymes.
258. Mechanisms
of Organic and Enzymatic Reactions
(3) Staff
Prerequisite: consent
of instructor. Lecture, 3 hours.
Formal presentation
of seminars on recent literature dealing with mechanisms of organic and
enzymatic reactions accompanied by open discussion of the topics considered.
259. Selected Topics
in Biological Chemistry
(1-4) Staff
Prerequisite: consent
of instructor. Course may be repeated with a different topic (18 units
maximum). Same course as Biochemistry-Molecular Biology 259. Lecture, 1
to 4 hours.
Selected topics from
bio-organic, biophysical, or biological chemistry. The contents of this
course will vary.
260. Research Seminar
in Biochemistry-Molecular Biology
(1) Faculty of
biological sciences and chemistry
Prerequisite: graduate
status. Seminar, 1-2 hours.
Seminars presented
by faculty of the chemistry department and the molecular biology-biochemistry
section of biological sciences. Current research topics.
261A-B-C. Enzyme
Mechanisms
(3-3-3) Parsons
Prerequisites:
Chemistry 142A-B-C or consent of instructor. Lecture, 3 hours.
Presentation of the
chemistry, structure, and function of enzymes followed by discussion of
pertinent organic model systems relating to the specific enzymes. (Normally
offered in alternate years.)
262. Drug Design
(3) Reich
Prerequisites:
Chemistry 142A-B-C or MCDB 108A-B-C, or consent of instructor. Same course
as Biochemistry and Molecular Biology 254. Lecture, 3 hours.
Rational drug design.
Active site-directed and mechanism-based inhibitors. The use of computers
and energy calculations in the design of drugs. Structure based drug design.
268A. Advanced Inorganic
Chemistry
(3) Staff
Prerequisite: consent
of the chemistry graduate advisor. Not open for credit to students who
have completed Chemistry 173A, or 272A. Lecture, 3 hours.
Electronic structure
of atoms and molecules. Models for bonding in molecules of nontransition
and transition elements. Applications of symmetry to bonding, electronic
and vibrational spectroscopy. Stereochemistry of transition metal complexes
and introduction to organometallics.
268B. Advanced Inorganic
Chemistry
(3) Staff
Prerequisite: consent
of the chemistry graduate advisor. Not open for credit to students who
have completed Chemistry 173B, or 272B. Lecture, 3 hours.
Structures of ordered
crystalline solids, x-ray crystallography. Introduction to solid state
chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
269. Crystallography
and Structure Determination
(4) Cheetham, Stucky
Prerequisites:
Chemistry 273 or consent of instructor.
Topics in structure
determination: structure factors, integrated intensities, data collection,
the phase problem, Patterson synthesis, direct methods, structure refinement,
Debye-Waller factors, thermal diffuse scattering and extinction. Rietveld
analysis of powder diffraction data. Synchrotron X-rays, neutron diffraction,
electron diffraction, non-crystalline materials.
270. Graduate Seminar
in Inorganic/Analytical Chemistry
(2) Staff
Prerequisite: graduate
standing. Seminar, 2 hours.
Seminars on current
research topics in Inorganic/Analytical Chemistry presented by faculty,
visiting scholars, and postdoctoral and senior graduate students.
271. Bioinorganic
Chemistry
(3) Staff
Prerequisites:
Chemistry 173A-B, or equivalent, or consent of instructor. Lecture, 3 hours.
Selected topics in
bioinorganic chemistry and metallobiochemistry with a major focus on recent
developments. Topics will include discussions of metalloproteins and corresponding
model compound investigations. Emphasis will be on reaction mechanisms
and spectroscopic properties of metal sites.
272. Reaction Mechanisms
in Organometallic and Inorganic Chemistry
(3) Staff
Prerequisites:
Chemistry 173A-B, or equivalent, or consent of instructor. Lecture, 3 hours.
Discussion of chemical
reaction mechanisms. Emphasis will be on fundamental reactions of metal
compounds such as substitution, addition, elimination, and redox reactions
for homogenous catalysis mechanisms and other complex systems.
273. Structural
Inorganic Chemistry
(3) Staff
Prerequisites:
Chemistry 173A-B and 175, or equivalent, or consent of instructor. Lecture,
3 hours.
The use of x-ray and
neuron scattering to characterize solid state materials. Subjects include
the crystal unit cell, space groups, structure determination and refinement.
It is recommended that the student have an elementary introduction to vectors,
matrices, and Fourier series.
274. Solid State
Inorganic/Materials
(3) Staff
Prerequisites:
Chemistry 173A-B, or equivalent, or consent of instructor. Same course
as Materials 274. Lecture, 3 hours.
An introductory course
describing the synthesis, physical characterization, structure, electronic
properties, and uses of solid state materials. (Normally offered in alternate
years.)
275. Physical-Inorganic
Chemistry
(3) Ford, Watts
Prerequisite: consent
of the chemistry graduate advisor. Lecture, 3 hours.
Bonding theory, thermodynamics,
and structure of inorganic compounds. Applications of physical techniques
to the study of inorganic (and organometallic) reactions and their mechanisms.
276. Photochemical
and Photophysical Properties of Inorganic and Organometallic Compounds
and Materials
(3) Staff
Prerequisites:
Chemistry 173A-B and 175, or equivalent, or consent of instructor. Lecture,
3 hours.
The mechanisms of
fundamental physical and chemical events which follow absorption of light
by inorganic or organometallic chromophores will be discussed. Homogeneous
and heterogeneous systems will be considered as well as the design and
operation of photo-optical and photoelectrical devices.
277. Introduction
to Inorganic Materials
(3) Cheetham
Prerequisite: Chemistry
274 or consent of instructor. Same course as Materials 218.
Structures of inorganic
materials: close-packing, linking of simple polyhedra. Factors that control
structure: ionic radii, covalency, ligand field effects, metal-metal bonding,
electron/atom ratios. Structure-property relationships in e.g. spinels,
garnets, perovskites, rutiles, fluorites, zeolites, B-aluminas, graphites,
common inorganic glasses.
278. Synthesis in
Organometallic and Inorganic Chemistry
(3) Staff
Prerequisites:
Chemistry 173A-B, or equivalent, or consent of instructor. Lecture, 3 hours.
The methodologies
of synthetic inorganic and organometallic chemistry will be discussed.
Of particular emphasis will be techniques of preparing and handling air
and moisture sensitive compounds and compound purification and crystallization.
(Normally offered in alternate years.)
279. Selected Topics
in Inorganic Chemistry
(1-4) Staff
Prerequisite: consent
of instructor. Course may be repeated with a different topic (18 units
maximum). Lecture, 3 hours.
This course is designed
to reflect recent developments in inorganic chemistry.
281. Protein Crystallography
(3) Perona, Kohlstaedt
Prerequisite: consent
of instructor. Same course as Biochemistry-Molecular Biology 281.
Introduction to diffraction
techniques. Protein crystal growth and morphology. Data collection and
reduction strategies. Approaches for solving the phase problem. Crystallographic
refinement, including molecular dynamics. Interpretation of crystal structures.
284. Chemical Literature
(2) Huber
Prerequisite: consent
of the chemistry graduate advisor only. Lecture, 3 hours.
Lectures and exercises
on the literature and other information resources of use in chemistry.
285. Synthetic Chemistry
of Macromolecules
(3) Wudl
Prerequisite: consent
of instructor. Same course as Materials 284. Lecture, 3 hours.
The course will cover
methods for the preparation of polymers. Organic chemistry synthetic reactions
will be reviewed with particular emphasis on functional groups that lead
to polymers.
290. Seminar in
Chemistry
(2) Little
Prerequisite: consent
of instructor. May be repeated for credit. Lecture, 1 hour.
Presentation of seminar
required of all chemistry graduate students.
291. Special Seminar
in Chemistry
(2) Staff
Prerequisite: consent
of instructor. May be repeated for credit. Lecture, 1 hour.
Specialized seminar
topics.
293. Faculty Research
Seminar
(2) Staff
Prerequisite: consent
of instructor. Seminar, 2 hours.
A series of seminars
by department faculty describing their active research projects.
501A-B-C. Techniques
of Teaching and Laboratory Class Supervision
(2-2-2) Lamb
Prerequisite: graduate
standing. S/U grade. Discussion, 1 hour.
An initial 2-3 day
workshop is followed by weekly discussion. Topics covered: laboratory organization,
supervising experiments, safety, presentations, leading discussions, writing
quizzes, advising, and grading. Aimed at new teaching assistants.
593. Preparation
for Organic Cumulative Examinations
(2) Staff
Discussion, 2 hours.
Discussion of (a)
the solutions to cumulative examinations; (b) how to prepare for cumulative
examinations; (c) problems in reaction mechanisms and organic synthesis.
594. Special Topics
(1-4) Staff
Variable hours.
Special seminar on
research subjects of current interest.
595. Group Studies
(2) Staff
Critical review of
research in selected fields. Regular meetings are held in which the student
presents for discussion information from the recent chemical literature.
596. Directed Reading
and Research
(2-12) Staff
No more than half
the units necessary for the master's degree may be taken in Chemistry 596.
Same course as Biochemistry-Molecular Biology 596CH. Tutorial, 2-8 hours.
Individual tutorial.
Instructor usually the student's major professor. A written proposal for
each tutorial must be approved by the department chair. Each faculty member
has a unique number designation.
597. Individual
Study for Master's Comprehensive Examinations and Ph.D. Examinations
(1-3) Staff
No unit credit
allowed toward advanced degree(s). S/U grade. Variable hours.
Instructor should
be the student's major professor or chair of the doctoral committee.
598. Master's Thesis
Research and Preparation
(1-12) Staff
No unit credit
allowed toward advanced degree. S/U grade. Variable hours.
Only for research
underlying the thesis, writing the thesis. Instructor should be the chair
of the student's thesis committee.
599. Ph.D. Dissertation
Research and Preparation
(1-12) Staff
S/U Grade. Variable
hours.
Only for research
underlying the dissertation, writing the dissertation. Instructor should
be the chair of the student's doctoral committee.