Department of Chemistry and Biochemistry,
Division of Mathematical, Life, and Physical Sciences,
Physical Sciences North 1631;
Telephone (805) 893-5675
Undergraduate e-mail: ugradprog@chem.ucsb.edu
Graduate e-mail: gradprog@chem.ucsb.edu
Website: www.chem.ucsb.edu (will open in a new browser window)
Department Chair: Alec M. Wodtke
Contents:
Donald H. Aue, Ph.D., Cornell University, Associate Professor (organic chemistry)
Guillermo C. Bazan, Ph.D., Massachusetts Institute of Technology, Professor (organic, materials, organometallic chemistry)
Jeffrey W. Bode, Ph.D., California Institute of Technology, Assistant Professor (organic chemistry)
Michael T. Bowers, Ph.D., University of Illinois, Professor (physical chemistry)
Frank L. Brown, Ph.D., Massachussetts Institute of Technology, Assistant Professor (theoretical/biophysical chemistry)
Paula Yurkanis Bruice, Ph.D., University of Virginia, Senior Lecturer (organic chemistry)
Thomas C. Bruice, Ph.D., University of Southern California, Research Professor (bio-organic chemistry)
Steven Buratto, Ph.D., California Institute of Technology, Associate Professor (physical chemistry)
Alison Butler, Ph.D., UC San Diego, Professor (bio-inorganic chemistry)
Anthony Cheetham, Ph.D., Oxford University, Professor (inorganic chemistry/materials)
Frederick W. Dahlquist, Ph.D., California Institute of Technology, Professor (biochemistry)
Mattanjah S. de Vries, Ph.D., University of Amsterdam, Professor (physical chemistry)
Peter C. Ford, Ph.D., Yale University, Professor (inorganic chemistry)
Song-I Han, Ph.D., Aachen University of Technology, Assistant Professor (physical chemistry)
Craig Hawker, Ph.D., University of Cambridge, Research Chemist (polymer chemistry)
Trevor Hayton, Ph.D., University of British Columbia, Assistant Professor (inorganic chemistry)
Alan Heeger, Ph.D., UC Berkeley, Professor (materials), Nobel Laureate (2000)
Thomas M. Hooker, Jr., Ph.D., Duke University, Professor (biophysical chemistry)
Luc Jaeger, Ph.D., University of Louis Pasteur of Strasbourg (France), Assistant Professor (biomaterials)
Bernard Kirtman, Ph.D., Harvard University, Professor (theoretical physical chemistry)
Kalju Kahn, Ph.D., University of Missouri, Lecturer with Potential Security of Employment (biochemistry)
Walter Kohn, Ph.D., Harvard University, Adjunct Professor, Nobel Laureate (chemical physics, 1998)
Leroy Laverman, Ph.D., UC Santa Barbara, Lecturer with Security of Employment (inorganic/analytical chemistry)
Bruce H. Lipshutz, Ph.D., Yale University, Professor (organic chemistry)
R. Daniel Little, Ph.D., University of Wisconsin, Professor (organic chemistry)
Horia I. Metiu, Ph.D., Massachusetts Institute of Technology, Professor (theoretical physical chemistry)
Martin Moskovits, Ph.D., University of Toronto, Professor (physical chemistry)
T.-Q. Nguyen, Ph.D., UC Los Angeles, Assistant Professor (physical, materials chemistry)
Stanley M. Parsons, Ph.D., California Institute of Technology, Professor (biological chemistry)
John Perona, Ph.D., Yale University, Professor (biological chemistry)
Thomas R. R. Pettus, Ph.D., University of Rochester, Associate Professor (organic and biological chemistry)
Kevin W. Plaxco, Ph.D., California Institute of Technology, Associate Professor (biological chemistry)
Norbert O. Reich, Ph.D., UC San Francisco, Professor (theoretical biophysical chemistry)
Martin Sagermann, Ph.D., Univeristy of Heidelberg (Germany), Assistant Professor (biochemistry)
Susannah Scott, Ph.D., Iowa State University, Professor (inorganic chemistry, chemical engineering)
Joan-Emma Shea, Ph.D., Massachussetts Institute of Technology, Associate Professor (theoretical biophysical chemistry)
Galen Stucky, Ph.D., Iowa State University, Professor (inorganic chemistry)
Petra A. M. Van Koppen, Ph.D., UC Santa Barbara, Lecturer with Security of Employment, (physical chemistry)
J. Herbert Waite, Ph.D., Duke University, Professor (bioloogical, organic, and materials chemistry)
Richard J. Watts, Ph.D., University of Colorado, Professor (inorganic chemistry)
Alec M. Wodtke, Ph.D., UC Berkeley, Professor (physical chemistry)
Fred Wudl, Ph.D., UC Los Angeles, Professor (organic chemistry)
Curtis B. Anderson, Ph.D., UC Los Angeles, Associate Professor Emeritus (organic chemistry)
Clifford A. Bunton, Ph.D., University College (London), Professor Emeritus (organic chemistry)
David O. Harris, Ph.D., UC Berkeley, Professor Emeritus (physical chemistry)
J. Thomas C. Gerig, Ph.D., Brown University, Professor Emeritus (bio-physical chemistry)
William C. Kaska, Ph.D., University of Michigan, Professor Emeritus (inorganic chemistry)
John H. Kennedy, Ph.D., Harvard University, Professor Emeritus (inorganic/analytical chemistry)
Richard M. Martin, Ph.D., University of Wisconsin, Professor Emeritus (physical chemistry)
Roger C. Millikan, Ph.D., UC Berkeley, Professor Emeritus (physical chemistry)
Henry W. Offen, Ph.D., UC Los Angeles, Professor Emeritus (physical chemistry)
Ralph G. Pearson, Ph.D., Northwestern University, Professor Emeritus (inorganic chemistry)
Glyn O. Pritchard, Ph.D., Manchester University, Professor Emeritus (physical chemistry)
Bruce Rickborn, Ph.D., UC Los Angeles, Professor Emeritus (organic chemistry)
The department offers programs leading to the B.S. degree in chemistry or biochemistry or the B.A. degree in chemistry. The B.S. degrees are intended for students interested in careers strongly dependent on chemical knowledge. Such careers are found in chemical, biochemical, and materials science research, and quality control in medicine. Graduates may enter the workforce directly or seek the highest levels of career attainment by enrolling in an appropriate graduate or professional school. The requirements of the B.S. degree in chemistry meet American Chemical Society standards for certification with appropriate choices of upper-division electives.
The B.A. degree in chemistry offers flexibility and is intended for students interested in careers having a significant chemical component such as environmental science, law, technical management, K-12 education, and business. Graduates may enter the workforce directly or seek higher levels of career attainment by enrolling in an appropriate professional program.
Entering majors will be assigned an advisor who should be consulted on departmental opportunities and program requirements. Students must submit their programs to the advisor for approval.
Students seeking a degree from the department and who also are interested in pursuing a California Teaching Credential should consult with the credential advisor in the Graduate School of Education soon after enrolling.
The Willard L. McRary Prize in Chemistry is given to a graduating senior whose work in chemistry reflects the promise of outstanding scientific achievement, such as that which characterized the career of Professor McRary. The B. R. Baker Memorial Fellowship in Chemistry is awarded to graduate students who have given strong indication, by their graduate or undergraduate record, that they will make continued and substantial contributions to the progress of organic, medicinal, or biological chemistry. The Robert H. DeWolfe Teaching Fellowship is awarded to a graduate student in organic chemistry who has demonstrated excellence in undergraduate instruction. The John H. Tokuyama Memorial Scholarship is awarded annually to an organic chemistry graduate student.The Roche Bio-Science Fellowships recognizes outstanding graduate and undergraduate students in organic chemistry.
Students who have achieved a grade-point average of 3.5 or above in their chemistry courses and submit a written report of their original research carried out under the guidance of a faculty member (through completion of chemistry 192) and approved by one additional member of the faculty shall be designated as having achieved a Distinction in the Major. Students contemplating this option should advise the undergraduate staff advisor of their intention at the beginning of their senior year.
Undergraduate Program
Bachelor of Science - Biochemistry
Preparation for the major. Chemistry 1A or 2A, 1B or 2B, 1C or 2C, and 1AL or 2AC, 1BL or 2BC, 1CL or 2CC; 6AL, 6BL, (or BH); 109A-B-C; Mathematics 3A-B-C and 5A; Physics 6A-AL-B-BL-C-CL; MCDB 1A-AL-B; EEMB 2, and either MCDB 1BL or EEMB 2L.
Upper-division major. Forty-six upper-division units, including Chemistry 110L, 112-112L, 113A-B, 125L, 142A-B-C, 173A; six units of core electives from Chemistry 141, 143, 145, 146, 147, 151, 154A-B, 161, 162A, 162B, 171, 181; five additional units from the above or from Chemistry 111, 115A-B-C, 117A, 118, 120, 123, 124, 126 (if 145 not completed), 127, 128, 129, 132, 133, 134, 150, 173B, 175, 176, and from the following MCDB courses: 101B, 103, 126B-C, 134, 135.
Bachelor of Science - Chemistry
Preparation for the major. Chemistry 1A or 2A, 1B or 2B, 1C or 2C, and 1AL or 2AC, 1BL or 2BC, 1CL or 2CC; 6AL, 6BL, (or BH), 6CL (or CH); 109A-B-C; Mathematics 3A-B-C, 5A-B; Physics 1-2-3-3L-4-4L.
Upper-division major. Forty-five upper-division units, including Chemistry 113A-B-C, 116AL-BL-CL, 142A, 150, 173A-B, are required. Chemistry 101, 193, and 196 will not apply. Chemistry 199 may be applied only by petition. Courses should be chosen after consultation with the junior or senior advisor.
Note: Transfer students receiving subject credit for Chemistry 150 must complete a minimum of 44 upper-division units in the Department of Chemistry and Biochemistry.
Preparation for the major. Chemistry 1A or 2A, 1B or 2B, 1C or 2C, and 1AL or 2AC, 1BL or 2BC, 1CL or 2CC; 6AL, 6BL, (or BH); Mathematics 3A-B-C. Physics 1, 2, 3, 4, 3L, 4L, or Physics 6A-B-C, 6AL-BL-CL are required. It is recommended but not required that Mathematics 5A be completed before taking Chemistry 113A-B-C.
Upper-division major. Thirty-nine upper-division units, including Chemistry 109A-B-C, 113A-B-C, 116AL-BL, 150, 173A. The final three elective units may not include the following: Chemistry 101, 193, 196, and 199.
Note: Transfer students receiving subject credit for Chemistry 109A-B-C and/or 150 must complete a minimum of 36 upper-division units in the Department of Chemistry and Biochemistry.
All courses to be applied to the minor must be completed on a letter-grade basis. This includes both courses offered in chemistry and those offered by other departments and applied to the minor.
Preparation for the minor. No specific courses are required for the minor in chemistry, but students should note that most upper-division chemistry courses include Chemistry 1A-B-C as prerequisite, and many require mathematics courses through 5A as prerequisite.
Upper-division minor. Twenty-three upper-division units, including at least one course (4 units) in physical chemistry (Chemistry 113A or 113B or 113C) and 150; and 16 units of additional upper-division chemistry courses (Chemistry 101, 193, 196, and 199 may not apply).
Note: Substitutions and waivers are subject to approval by the chair of the department. Please see "Academic Minors" for special conditions governing minors in the College of Letters and Science.
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Graduate Program
Admission
The M.S., M.A., or Ph.D. degrees may be obtained in any one of the special fields of analytical, biological, inorganic, organic, materials, physical, or theoretical chemistry. In addition to departmental requirements, candidates for graduate degrees must meet university degree requirements found in the section "Graduate Education at UCSB.” In addition to fulfilling the departmental admission requirements, applicants must also meet the university requirements for admission described in the section "Graduate Education at UCSB.” Graduate Study in Chemistry, a publication containing admission and degree requirements, is available upon request from the Department of Chemistry and Biochemistry.
Applications are accepted all year long for fall, winter, and spring quarters. However, January 15 is the priority deadline for fall applications and for campuswide fellowship competition.
Master of Science or Master of Arts - Chemistry
The M.S. in chemistry may be attained under Plan 1 (thesis based on research). The M.A. in chemistry may be obtained under Plan 2 (examination). The student must present a literature-based seminar to the department (both plans). The Department of Chemistry and Biochemistry emphasizes graduate work leading to the Ph.D.
Doctor of Philosophy - Chemistry
The Ph.D. degree in chemistry will be awarded upon the successful completion of the following requirements: (1) a core curriculum; (2) two preliminary evaluations; (3) a seminar presentation unrelated to the dissertation research field; (4) the Ph.D. oral qualifying examination for advancement to candidacy; and (5) submission and successful defense of a research dissertation. The main features and time schedule of these requirements are briefly summarized below; a complete document is available in the department.
A six-course curriculum is established with and approved by the divisional academic advisor and normally completed during the first year. Several additional elective courses will be taken during the first and second year. The two preliminary evaluations include written examinations, propositions, and cumulative examinations, depending on the division. Typically, all requirements and the seminar presentation must be completed before the Ph.D. oral qualifying examination. The Ph.D. qualifying oral examination, which focuses on the student’s dissertation research field, is usually scheduled for the end of the sixth quarter.
Ph.D. candidates will prepare and defend a dissertation detailing an original work of research in their field of specialization.
Interdepartmental Graduate
Program in Biomolecular Science and Engineering
For details see section entry under Biomolecular Science
and Engineering.
Interdepartmental Graduate
Program in Marine Science
For details see catalog entry under Marine Science.
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Chemistry and Biochemistry Courses
1A. General Chemistry
(3) Staff
Recommended preparation: concurrent enrollment in Chemistry 1AL; high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2A. Lecture, 3 hours.
Stoichiometry, chemical reactions, gas laws and kinetic theory, chemical equilibrium and acid-base chemistry. (F,W,S)
1AL. General Chemistry Laboratory
(2) Staff
Prerequisite: Chemistry 1A or 2A (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1AC or 2AC. Lab fee required. Laboratory, 4 hours.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium and acid-base chemistry. (F,W,S)
1B. General Chemistry
(3) Staff
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-.
Recommended preparation: Chemistry 1AL or 2AC; concurrent enrollment in Chemistry 1BL; high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2B. Lecture, 3 hours.
Thermodynamics (1st and 2nd laws), electrochemistry, chemical kinetics, atomic and molecular structure, and chemical bonding. (W,S)
1BL. General Chemistry Laboratory
(2) Staff
Prerequisite: Chemistry 1A or 2A with a minimum grade of C-; and, Chemistry 1AL or 2AC with a minimum grade of C-; and, Chemistry 1B or 2B (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1BC or 2BC. Laboratory, 3 hours; discussion, 1 hour.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate basic concepts of thermochemistry, electrochemistry, chemical kinetics, and atomic spectroscopy. (W,S)
1C. General Chemistry
(3) Staff
Prerequisite: Chemistry 1B or 2B with a minimum grade of C-.
Recommended preparation: Chemistry 1BL or 2BC; concurrent enrollment in Chemistry 1CL; high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2C. Lecture, 3 hours.
Chemical bonding, liquids and solids, properties of solution, structure and dynamics of elements and their compounds. Aspects of technology and environmental problems. (F,S)
1CL. General Chemistry Laboratory
(2) Staff
Prerequisites: Chemistry 1B or 2B with a minimum grade of C-; and, Chemistry 1BL or 2BC with a minimum grade of C-; and, Chemistry 1C or 2C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1CC or 2CC. Laboratory, 3 hours; discussion, 1 hour.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of solutions, intermolecular forces, colligative properties, and synthetic organic and inorganic chemistry. (F,S)
2A. General Chemistry (Honors)
(3) Staff
Recommended preparation: concurrent enrollment in Chemistry 2AC; high-school chemistry or physics, one quarter of calculus (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1A. Lecture, 3 hours.
The sequence of topics will be similar to that in Chemistry 1A. Calculus will be used as needed, at the level of the concurrent Mathematics 3A course. (F)
2AC. General Chemistry Laboratory (Honors)
(2) Staff
Prerequisite: Chemistry 2A (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1AC or 1AL. Laboratory, 3 hours; discussion, 1 hour.
Qualitative and quantitative measurements to develop laboratory technique and demonstrate the basic concepts of stoichiometry, chemical bonding, gas laws, chemical equilibrium and acid-base chemistry. Students work in small groups to develop a unique perspective on the experiment. (F)
2B. General Chemistry (Honors)
(3) Staff
Prerequisite: Chemistry 1A or 2A with a minimum grade of B.
Recommended preparation: Chemistry 1AL or 2AC with a grade of B or better; and concurrent enrollment in Chemistry 2BC; high-school algebra, chemistry and physics, and one quarter of calculus .
Not open for credit to students who have completed Chemistry 1B. Lecture, 3 hours.
Thermodynamics (1st and 2nd law), electrochemistry, chemical kinetics, atomic and molecular structure, and chemical bonding. (W)
2BC. General Chemistry Laboratory (Honors)
(2) Staff
Prerequisite: Chemistry 1A or 2A with a minimum grade of B; and, Chemistry 1AL or 2AC with a minimum grade of B; and, Chemistry 2B (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1BC or 1BL. Laboratory, 3 hours; discussion, 1 hour.
Laboratory techniques. Thermochemistry, electrochemistry, chemical kinetics, and atomic spectroscopy. Students work in small groups to develop a unique perspective on the experiment.
2C. General Chemistry (Honors)
(3) Staff
Prerequisite: Chemistry 1B or 2B with a minimum grade of B.
Recommended preparation: Chemistry 1BL or 2BC with a minimum grade of B; and, concurrent enrollment in Chemistry 2CC; high-school algebra, chemistry and physics, and one quarter of calculus .
Not open for credit to students who have completed Chemistry 1C. Lecture, 3 hours.
Structure and dynamics of the elements and their compounds. Aspects of technology and environmental problems. Laboratory required. (S)
2CC. General Chemistry Laboratory (Honors)
(2) Staff
Prerequisite: Chemistry 1B or 2B with a minimum grade of B; and, Chemistry 1BL or 2BC with a minimum grade of B; and, Chemistry 2C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1CC or 1CL. Laboratory, 3 hours; discussion, 1 hour.
Laboratory techniques. Solutions, colligative properties, and synthetic organic and inorganic chemistry. Students work in small groups to develop a unique perspective on the experiment. (S)
6A. Laboratory Methods of Organic Chemistry
(2) Staff
Prerequisite: Chemistry 109A (may be taken concurrently). Lecture, 1 hour; Laboratory, 4 hours.
Distillation, crystallization, extraction, determination of physical properties, spectroscopy, and instrumental methods in organic chemistry. (F,W,S)
6AL. Laboratory Methods of Organic Chemistry
(3) Staff
Prerequisite: Chemistry 109A (may be taken concurrently). Lecture, 2 hours; Laboratory, 4 hours.
Distillation, crystallization, extraction, determination of physical properties, spectroscopy, and instrumental methods in organic chemistry.
6B. Laboratory Methods of Organic Chemistry
(2) Staff
Prerequisites: Chemistry 6A and 109A with a minimum grade of C-; and, Chemistry 109B (may be taken concurrently).
Not open for credit to students who have completed Chemistry 7B. Lab fee required. Laboratory, 8 hours.
Application of organic techniques for organic reactions with use of instrumental methods. (F,W,S)
6BH. Laboratory Methods of Organic Chemistry (Independent Research)
(3) Staff
Prerequisites: Chemistry 6A and 109A; and Chemistry 109B (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only; consent of instructor. Discussion, 1 hour; Laboratory, 7 hours.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry. (W,S)
6BL. Laboratory Methods of Organic Chemistry
(3) Staff
Prerequisites: Chemistry 6A and 109A with a minimum grade of C-; and Chemistry 109B (may be taken concurrently). Discussion, 1 hour; Laboratory, 7 hours.
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
6C. Organic Chemistry Labs
(2) Staff
Prerequisites: Chemistry 6B and 109B with a minimum grade of C-; and, Chemistry 109C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 7C. Lab fee required. Laboratory, 8 hours.
Multistep organic synthesis, vacuum distillation, NMR, IR, MS, macro-scale and micro-scale techniques required for a B.S. in chemistry. (S)
6CH. Organic Chemistry Labs
(3) Staff
Prerequisites: Chemistry 6B and 109B; and, Chemistry 109C (may be taken concurrently); open to chemistry, biochemistry and creative studies majors only.
Not open for credit to students who have completed Chemistry 7C. Lab fee required. Discussion, 1 hour; Laboratory, 7 hours.
Independent research involving distillation, crystallization, extraction, determination of physical properties, organic synthesis, and use of instrumental methods in organic chemistry for the purposes of multistep synthesis.
6CL. Organic Chemistry Labs
(3) Staff
Prerequisites: Chemistry 6B and 109B with a minimum grade of C-; and Chemistry 109C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 7C. Lab fee required. Discussion, 1 hour; Laboratory, 7 hours.
Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.
10. Introduction to Chemical Computing
(2) Staff
Introduction of different computing techniques for computation in UNIX. Applications include: molecular modeling, molecular dynamics, mathematica, Monte Carlo, data analysis, and data mining.
99. Introduction to Research
(1-3) Staff
Prerequisite: consent of instructor.
May be repeated to a maximum of 6 units. Students are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199AA-ZZ courses combined. Tutorial, 3-9 hours.
Directed study, normally experimental, to be arranged with individual faculty members. Course offers exceptional students an opportunity to participate in a research group. Basic techniques and the operation of instruments used in research.
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101. Problems in Environmental Chemistry
(3) Staff
Prerequisites: Chemistry 1A-B; or, Chemistry 2A-B. Lecture, 3 hours.
The chemical aspects of energy sources and their impact on the environment; the chemistry of air, water, and soil pollution; sources and methods of control; chemical dynamics in the environment; chemical quality standards and their maintenance.
109A. Organic Chemistry
(4) Aue, Bode, Bruice, Lipshutz, Little, Pettus
Prerequisite: Chemistry 1C or 2C with a minimum grade of C-; or, Chemistry 1B or 2B with a minimum grade of B-.
Not open for credit to students who have completed Chemistry 107A or 130A.
Structure, reactivity, and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acids, proteins, nucleic acids, coenzymes, and their mechanisms. (F,W,S)
109B. Organic Chemistry
(4) Aue, Bode, Bruice, Lipshutz, Little, Pettus
Prerequisite: Chemistry 109A with a minimum grade of C-.
Not open for credit to students who have completed Chemistry 107B or 130B.
Structure, reactivity, and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acids, proteins, nucleic acids, coenzymes, and their mechanisms. (F,W,S)
109C. Organic Chemistry
(4) Aue, Bode, Bruice, Lipshutz, Little, Pettus
Prerequisite: Chemistry 109B with a minimum grade of C-.
Not open for credit to students who have completed Chemistry 108 or 130C.
Structure, reactivity, and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acids, proteins, nucleic acids, coenzymes, and their mechanisms. (F,W,S)
110L. Introductory Biochemistry Laboratory
(4) Staff
Prerequisite: Chemistry 142A (may be taken concurrently).
Lab fee required.
Recommended preparation: Chemistry 6A-B-C; Chemistry 107A-B and 108, or Chemistry 109A-B-C; Chemistry 150 (may be taken concurrently).
Gives students hands-on experience with modern methods of separation, identification, and study of biomolecules and macromolecular structures. (F)
111. Chemical Kinetics
(3) Staff
Prerequisite: consent of instructor. Lecture, 3 hours
The laws and theories governing rates of chemical reactions and reaction mechanisms. Empirical treatment of reaction rates, treatment of data, gas-phase reactions, reactions in solution, catalysis, complex reactions, chain reactions. Collision theory and potential energy surfaces.
112. Biophysical Chemistry
(4) Brown, Sagermann
Prerequisites: Chemistry 113A-B.
Thermodynamics, kinetics, and quantum chemistry with special emphasis on biological systems. Some examples of special emphasis: diffusion across and within membranes, diffusion along DNA, phase equilibria and protein folding, spectroscopy (fluorescence, mass spectroscopy, FTIR, NMR), electron transfer and hydrogen bonding. (S)
112L. Biophysical and Bioanalytical Laboratory
(3) Staff
Prerequisite: Chemistry 110L, 113A, and Chemistry 142A-B-C (may be taken concurrently). Lab fee required.
Recommended preparation: Chemistry 112 (may be taken concurrently), Chemistry 113B, and 125L.
Application of modern biophysical and bioanalytical techniques to study the structure, function, and properties of biomolecules. Fluorescence spectroscopy, mass spectroscopy, FTIR, 2D-NMR, diffraction techniques, circular dichroism. (S)
113A. Physical Chemistry
(4) Bowers, Buratto, Metiu, Shea , Wodtke
Prerequisites: Chemistry 1C or 2C; and, Mathematics 3A-B-C; and, Physics 1-2-3-3L-4-4L, or
Physics 6A-B-C-AL-BL-CL.
Recommended preparation: Chemistry 113AL (may be taken concurently). Lecture, 3 hours; discussion, 1 hour.
Chemical thermodynamics: laws of thermodynamics, phase equilibria, chemical equilibria, equations of state. (F)
113AG. Physical Chemistry
(4) Bowers, Buratto, Metiu
Prerequisite: graduate standing.
Not open for credit to students who have taken Chemistry 113A-B-C or the respective part thereof in this institution. Lectures, 3 hours; discussions, 1 hour.
Same description as Chemistry 113A-B-C. (F)
113AL. Physical Chemistry Laboratory
(3) Metiu, Wodtke
Prerequisite: Chemistry 113A (may be taken concurrently).
Recommended preparation: Chemistry 150 or equivalent. Lecture, 2 hours; laboratory, 8 hours. Lab fee required.
Lecture: instrumental techniques, data analysis, error analysis, instruction in MathematicaR. Laboratory: MathematicaR, a symbolic programming language, is taught in the computer laboratory. (F)
113B. Physical Chemistry
(4) Bowers, Buratto, Metiu, Wodtke
Prerequisite: Chemistry 113A or Chemical Engineering 110A-B.
Recommended preparation: Chemistry 116AL and 150 (may be taken concurently). Lecture,
3 hours; discussion, 1 hour.
Quantum theory and spectroscopy: introduction to quantum mechanics; symmetry, molecular structure, and spectroscopy. (W)
113C. Physical Chemistry
(4) Bowers, Buratto, Metiu, Wodtke
Prerequisite: Chemistry 113B.
Recommended preparation: Chemistry 113AL and 116BL (may be taken concurrently). Lecture,
3 hours; discussion, 1 hour.
Kinetic theory of gases, chemical kinetics, statistical mechanics, photochemistry. (S)
115A-B-C. Fundamentals of Quantum Chemistry
(3-3-3) De Vries, Han, Kirtman, Wodtke
Prerequisites: Mathematics 5A and Chemistry
113A-B-C. Lecture, 3 hours.
A. Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications. (F)
B. Molecular orbital theory and valence bond theory; Huckel theory (secular eqn.) applications to conjugated systems. Electronic spectra, and term symbols; introduction to infrared, Raman, and microwave spectroscopy. (W)
C. Introduction to NMR, EPR, group theory; applications. (S)
116AL. Quantitative Analytical and Physical Methods Laboratory
(3) Laverman
Prerequisites: Chemistry 150 (may be taken concurrently); and Chemistry 113B (may be taken concurrently).
Lab fee required. Lecture, 1 hours; Laboratory,
8 hours.
Principles of analytical chemistry including spectroscopy, classical techniques and separation processes. Quantitative analysis of unknowns. Introduction to instrumental analysis. (W)
116BL. Advanced Physical Chemistry Laboratory
(3) Laverman
Prerequisites: Chemistry 150 and 116AL; Chemistry 113C (may be taken concurrently).
Lab fee required. Lecture, 1 hourss; laboratory,
8 hours.
Experiments in thermodynamics, spectroscopy and electrochemistry. Synthesis and study of inorganic complexes. Instrumental techniques such as NMR, fluorescence, Raman and laser flash photolysis are explored. Methods of data and error analysis. (S)
116CL. Inorganic Synthesis and Physical Characterization Laboratory
(3) Laverman
Prerequisites: Chemistry 150 and 116BL; Chemistry 173A (may be taken concurrently).
Lab fee required. Lecture, 1 hour; laboratory,
8 hours.
Synthesis of inorganic and organometallic complexes including techniques for air-sensitive materials. Instrumental characterization and study of synthesized compounds in a research-like setting. (F)
117A. Statistical Mechanics
(3) Brown, Metiu, Shea
Prerequisites: Chemistry 113A-B-C. Lecture, 3 hours.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
118. Photochemistry and Radiation Chemistry
(3) Buratto, Devries
Prerequisites: Chemistry 113A-B-C and 150. Lecture, 3 hours.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.
120. Polymer Chemistry
(3) Bazan
Prerequisites: Chemistry 1C or 2C; and, Chemistry 107A-B-C or 109A-B-C.
Mechanism and kinetics of polymerization: vinyl, condensation, and diene polymers; ionic polymerizations; block and graft polymers; copolymerization; physical chemistry of high polymers; polymer degrations; radiation chemistry of polymer systems.
123. Fundamentals of Environmental Chemistry
(3) De Vries, Perona, Watts
Prerequisites: Chemistry 1A-B.
Recommended preparation: Chemistry 1C.
Chemical matters of pollution sources. Principles of analytical monitoring and control of pollution sources. The chemistry of pollutants in the environment. Chemical quality standards and chemical monitoring of the environment.
124. Organic Spectroscopic Analysis
(3) Aue, Bazan, Little, Pettus
Prerequisites: Chemistry 107A-B or 109A-B; and Chemistry 6A. Lecture, 3 hours; laboratory, 1 hour.
Recommended preparation: Chemistry 107C or 109C.
Structure determination of complex organic molecules. Topics covered include NMR, IR, UV, and mass spectrometry.
125L. Laboratory Techniques in Biochemistry
(4) Staff
Prerequisites: Chemistry 110L; and Chemistry 142A-B (may be taken concurrently).
Lab fee required.
Recommended preparation: Chemistry 6A-B-C; and, Chemistry 109A-B-C.
Application of molecular biology techniques to perform mutagenesis and cloning; restriction endonucleases, PCR, plasmid purification and DNA analysis. Protein purification and analysis methods: expression of proteins in bacterial systems. (W)
126. Computation Chemistry and Molecular Modeling
(3) Aue, Brown, Kahn, Shea
Prerequisites: Chemistry 109A-B.
Same course as EEMB 126MM. Lecture, 3 hours; laboratory, 3 hours.
Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics, and computer graphical interfaces to problems in chemistry, biochemistry, drug design, and pharmacology.
127. Structure and Reactivity in Organic Chemistry
(3) Aue, Bode, Lipshutz, Little, Pettus
Prerequisites: Chemistry 107A-B-C or 109A-B-C. Lecture, 3 hours.
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
128. Organic Reaction Mechanisms
(3) Aue, Bode, Lipshutz, Little, Pettus
Prerequisites: Chemistry 107A-B-C or 109A-B-C.
Recommended preparation: Chemistry 127. Lecture, 3 hours.
Mechanisms of thermal, photochemical, organometallic, electrochemical asymmetric or other processes in organic chemistry.
129. Synthetic Organic Reactions
(3) Aue, Bode, Lipshutz, Little, Pettus
Prerequisites: Chemistry 107A-B-C or 109A-B-C. Lecture, 3 hours.
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and stereochemical issues.
132. Organometallics in Organic Synthesis
(3) Lipshutz
Prerequisites: Chemistry 109A-B-C and Chemistry 129; upper-division standing. Lecture, 3 hours.
Synthetic methods and applications to natural products total syntheses involving transition metals.
133. Advanced Synthetic Chemistry
(3) Bode, Lipshutz, Little, Pettus
Prerequisites: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only. Lecture, 3 hours.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.
134. Chemical Synthesis of Biological Molecules
(3) Bode
Prerequisites: Chemistry 129; upper-division standing. Lecture, 3 hours.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems. (S)
141. Epigenetics: Biology, Mechanisms and Therapies
(3) Reich
Prerequisites: Chemistry 142A-B-C or MCDB 108A-B-C; upper-division standing. Lecture, 3 hours.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
142A. Biochemistry
(3) Kahn, Parsons, Plaxco
Prerequisites: Chemistry 107A-B-C or 109A-B-C. Lecture, 3 hours.
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules. (F)
142B. Biochemistry
(3) Parsons, Perona, Plaxco
Prerequisite: Chemistry 142A. Lecture, 3 hours.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation. (W)
142C. Biochemistry
(3) Jaeger, Reich
Prerequisite: Chemistry 142B. Lecture, 3 hours.
Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility. (S)
143. The RNA World
(3) Jaeger
Prerequisites: Chemistry 142A-B-C; or, MCDB
108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
145. Computational Biochemistry
(3) Shea
Prerequisites: Chemistry 113A-B; and, Chemistry 142A or MCDB 108A.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.
146. Membrane Biochemistry
(3) Parsons
Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Introduction to the structures and roles of lipids and their phase behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.
147. Astrobiology and the Origins of Life
(3) Plaxco
Prerequisite: Chemistry 142A. Lecture, 3 hours.
Discusses the origins and evolution of the solar system and the earth, the origins and evolution of life on earth and the possibilities for life elsewhere in the cosmos all from the perspective of contemporary, terrain biochemistry.
150. Analytical Chemistry
(3) Buratto, De Vries, Nguyen
Prerequisites: Chemistry 1A-B-C or 2A-B-C.
Recommended preparation: Chemistry 116AL (may be taken concurrently). Lecture, 3 hours.
Principles of analytical chemistry including classical techniques, spectrophotochemistry, electroanalytical techniques, and separation processes. (W)
151. Post-translational Protein Processing
(4) Waite
Prerequisites: MCDB 108A or Chemistry 142A with a grade of C or better.
Same course as MCDB 145. Lecture, 3 hours; discussion, 1 hour.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abolones, mussels, and fish as well as others.
153. Advanced Analytical Techniques
(3) Nguyen, Watts
Prerequisite: Chemistry 150. Lecture, 2 hours; laboratory, 4 hours. Lab fee required.
Principles of analytical methodology, as in spectroscopy, electronanalysis, and chromatography. Applications to environmental problems, forensic and clinical analysis, and industry. Analysis of solids and surfaces.
154A-B. Magnetic Resonance in Biological Systems
(3-3) Staff
Prerequisites: Chemistry 113A-B; and, Chemistry 112 or 133C (may be taken concurrently). Lecture, 3 hours.
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
161. Enzyme Mechanisms
(3) Reich
Prerequisites: Chemistry 142A-B-C; or
MCDB 108A-B-C.
Chemistry, structure and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.
162A. Drug Design
(3) Kahn, Reich
Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Recommended preparation: MCDB 101A-B or Chemistry 126, 145 or 161. Lecture, 3 hours.
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure based drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
162B. Drug Design
(3) Kahn, Reich
Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Recommended preparation: Chemistry 127, 129 or 162A. Lecture, 3 hours.
Medicinal chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmacokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
163. Arrow Pushing in Organic Chemistry
(2) Staff
Prerequisites: Chemistry 109A-B-C; upper-division standing; open to chemistry and biochemistry majors only.
Designed for majors
Recommended preparation: taken or concurrently enrolled in one of the following; Chemistry 127, 128, 129, or 133. Lecture, 2 hours.
Covers the arrow pushing formulasism and addresses molecular rearrangements and other organic reactions from this perspective. (F)
171. Bioinorganic Chemistry
(3) Butler
Prerequisite: Chemistry 173A.
Selected topics in bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reactions mechanisms and spectroscopy or properties of metal sites.
173A. Advanced Inorganic Chemistry
(3) Ford, Stucky
Prerequisites: Chemistry 113A; and, Chemistry
113B-C, or Chemistry 112. Lecture, 3 hours.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics. (F)
173B. Advanced Inorganic Chemistry
(3) Ford, Stucky
Prerequisite: Chemistry 173A. Lecture, 3 hours.
Structures of ordered crystalline solids, X-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry. (W)
175. Physical-Inorganic Chemistry
(3) Ford
Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
176. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) Ford
Prerequisite: Chemistry 173A. Lecture, 3 hours.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
181. Protein Crystallography
(3) Sagermann
Prerequisite: consent of instructor.
Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structure.
184. Chemical Literature
(2) Huber
Prerequisites: prior enrollment in 3 chemistry courses. Lecture, 2 hours.
Lectures and exercises on the literature and other information resources of use in chemistry. (W)
192. Honors Research Seminar
(3) Staff
Prerequisites: upper-division standing; consent of instructor and department.
Must have a minimum 3.5 GPA. No units may be applied to the major. An application must be completed and submitted to the undergrad advisor in the first quarter of their senior year. Students successfully completing the program are eligible to graduate with Distinction in the Major.
Independent research project carried out under the supervision of faculty member. Goal is to write an original, publishable research paper. The project can be on a topic of the student’s choice, or it can be an extension of an ongoing research project under the direction of a faculty member in the department.
193. Internship in Chemistry
(1-3) Staff
Prerequisites: upper-division standing; consent of instructor.
Must have a minimum 3.0 GPA. No units may be applied to the major. An application must be completed and submitted to the department research advisor prior to the internship.
Opportunity to obtain practical nonpaid chemistry-related research experience by working under faculty direction as an intern with local, state, federal, or private agencies. A formal written report is required for credit, which is evaluated by the department research advisor.
195. Chemical Instrumentation
(3-5) Staff
Prerequisite: consent of instructor. Discussion, 1 hour; laboratory, 6 to 12 hours.
With guidance from a faculty member students learn advanced laboratory techniques by independent experimental work and weekly consultations with the instructor. This course may be used to satisfy the upper-division laboratory requirement.
196. Special Topics
(1-4) Staff
Prerequisite: consent of instructor.
May be applied to major requirements by petition only. Tutorial, 3-12 hours.
Special topics and courses as a means of meeting special curriculum needs.
199. Independent Studies in Chemistry and Biochemistry
(1-5) Staff
Prerequisites: upper-division standing in the major; completion of two upper-division courses in chemistry.
Must have a minimum 3.0 grade-point average for the preceding three quarters. Students are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199AA-ZZ courses combined. Not applicable to the B.A. in Chemistry. No more than 12 units of Chemistry 199 may apply toward the B.S. in Chemistry. Tutorial, 1-5 hours.
Coursework shall consist of academic research supervised by a faculty member. This course is not intended for internship credit.
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203. Combinatorial Methods in Chemistry and Chemical Engineering
(3) McFarland
Prerequisite: prior coursework in inorganic and organic chemistry; consent of instructor.
Same course as Chemical Engineering 203 and Materials 223. Lecture, 3 hours.
Foundation and methodologies of chemical, biological, and materials research and discovery using automated, high-speed synthesis and screening. Emphasis on the chemical, biochemical, physical, and mathematical fundamentals necessary for experimental design, synthesis, high-throughput screening and analysis of combinatorial libraries.
217A. Statistical Mechanics
(3) Brown, Metiu, Shea
Prerequisite: consent of graduate advisor.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.
217B. Statistical Mechanics
(3) Brown, Metiu, Shea
Prerequisite: consent of graduate advisor.
Fundamentals of non-equilibrium statistical mechanics, kinetic theory of gases, Boltzmann equation, correlation functions, linear response theory, fluctuation-dissipation theorem, Langevin and Fokker-Planck equations.
217C. Statistical Mechanics
(3) Brown, Metiu, Shea
Prerequisite: consent of graduate advisor.
Not open for credit to students who have completed Chemistry 117A.
Selected topics in advanced statistical mechanics. Phase transitions and the renormalization group. Theory of rate processes.
218. Photochemistry and Radiation Chemistry
(3) Buratto, De Vries
Prerequisite: consent of the chemistry graduate advisor.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.
219. Selected Topics in Physical Chemistry
(1-4) Staff
Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 1 to 4 hours.
Selected topics: orbital symmetry rules for chemical reactions (Pearson); classical theory of light, radiation, and spectroscopy (Metiu); nonlinear optics and nonlinear spectroscopy (Metiu).
222A-B-C. Fundamentals of Quantum Chemistry
(3-3-3) de Vries, Han, Kirtman, Wodtke
Prerequisites: consent of the graduate advisor; graduate standing.
Not open for credit to students who have completed Chemistry 115A-B-C.
A. Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; lineral operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications. (F)
B. Molecular orbital theory and valence bond theory (secular equ.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared Raman, and microwave spectroscopy. (W)
C. Introduction to NMR, EPR, Group Theory; applications. (S)
223. Current Events in Organic Chemistry
(2) Staff
Recommended preparation: Chemistry 109A-B-C. Lecture, 2 hours.
Faculty and students present and critically discuss current chemical literature.
224. Organic Spectroscopic Analysis
(3) Staff
Lecture, 3 hours; discussion, 1 hour.
Structure determination of complex organic molecules. Topics include NMR, IR, UV, and mass spectroscopy.
225. Instrumental Methods in Physical Chemistry
(3) Bowers, Buratto, de Vries, Wodtke
Prerequisite: consent of instructor.
Advanced undergraduates may enroll by petition to their college office. Lecture, 3 hours.
Fundamentals of basic measurements and advanced research instrumentation are taught. Emphasis is on both practical and conceptual understanding of the methods, suitable for experimental design. Signal electronics, vacuum techniques, molecular beams, lasers, and optics.
226. Computational Chemistry
(3) Aue, Brown, Shea
Lecture, 3 hours; laboratory, 3 hours.
Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics, and computer graphical interfaces to problems in chemistry, biochemistry, drug design and pharmacology.
227. Structure and Reactivity in Organic Chemistry
(3) Aue, Bode, Lipshutz, Little, Pettus
Lecture, 3 hours.
Electronic structure, resonance, acid/base chemistry, thermodynamics, kinetics, transition state theory, and isotope effects.
228. Organic Reaction Mechanisms
(3) Aue, Bode, Lipshutz, Little, Pettus
Lecture, 3 hours.
Mechanisms of thermal, photochemical, organometallic, electrochemical, asymmetric or other processes in organic chemistry.
229. Synthetic Organic Reactions
(3) Aue, Bode, Lipshutz, Little, Pettus
Lecture, 3 hours.
A survey of reactions of organic substances with emphasis on those with practical synthetic utility, including discussion of mechanism, scope and limitations, and stereochemical issues.
230. Modern Instrumental Techniques in Organic Chemistry
(3) Staff
Prerequisite: graduate standing. Lecture, 3 hours.
Practical spectroscopy including infrared and ultraviolet, but with primaryemphasis on nuclear magnetic resonance, electron spin resonance, and mass spectroscopy.
232. Organometallics in Organic Synthesis
(3) Lipshutz
Prerequisites: Chemistry 109A-B-C; and, Chemistry 129 or 229; graduate standing.
Designed for majors.
Recommended preparation: Chemistry 233.
Synthetic methods and applications to natural products total syntheses involving transition metals.
233. Advanced Synthetic Chemistry
(3) Pettus
Prerequisite: consent of instructor. Lecture, 3 hours.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.
234. Chemical Synthesis of Biological Molecules
(3) Bode
Prerequisites: Chemistry 229; graduate standing; consent of instructor. Lecture, 3 hours.
The synthesis, manipulation, and modification of biological molecules including peptides, carbohydrates, nucleic acids, and other metabolites are essential to advances in biomedicine. This course surveys chemical methods for the production of these molecules and their application to biological problems. (S)
239. Selected Topics in Organic Chemistry
(1-4) Aue, Bazan, Bode, Lipshutz, Little, Pettus
Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 3 hours.
Selected topics in organic chemistry. The contents of this course will vary.
241. Epigenetics: Biology, Mechanisms and Therapies
(3) Reich
Prerequisites: Chemistry 142A-B-C or MCDB 108A-B-C; graduate standing. Lecture, 3 hours.
Covers epigenetic processes and molecular mechanisms in bacteria, fungi, plants, mammals, imprinting, gene regulation, repeat-induced point mutation (RIP), X- chromosome inactivation, epigenetic mechanisms including DNA methylation, histone modification, chromatin remodeling, RNA silencing, and epigentically based therapeutics and pharmaco-epigenetics.
242A-B-C. Chemical Aspects of Biological Systems
(3) Parsons, Perona, Plaxco, Reich, jaeger
Prerequisite: consent of the chemistry graduate advisor.
A. Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules. (F)
B. Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation. (W)
C. Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility; neurochemistry. (S)
243. The RNA World
(3) Perona
Prerequisites: Chemistry 142A-B-C or MCDB
108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.
244. Informational Macro- and Supra-Molecules
(2) Jaeger
Prerequisite: consent of instructor.
Same course as BMSE 244.
Selected topics at the interface of chemistry and biology: informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding of catalytic properties, biopolymer-based materials, special emphasis on cutting-edge technologies.
245. Computational Biochemistry
(3) Perona, Reich
Prerequisites: Chemistry 113A or 112 or 142A-B-C or Chemistry 113A-B-C.
Same course as Biochemistry-Molecular Biology 245.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.
246. Membrane Biochemistry
(3) Parsons, Reich
Prerequisites: Chemistry 142A-B-C.
Same course as Biochemistry-Molecular Biology 246.
Introduction to the structures and roles of lipids and their behavior, lipsomes, membrane proteins and kinetics, protein sorting, and signal transduction.
251. Post-Translational Protein Processing
(4) Waite
Prerequisite: MCDB 108A or MCDB 218A or Chemistry 142A or equivalent. Lecture, 3 hours; discussion, 1 hour.
Same course as MCDB 245.
Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others.
254A-B. Magnetic Resonance in Biological Systems
(3-3) Staff
Prerequisite: graduate standing. Lecture, 3 hours.
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.
257. Stategy in Organic Synthesis and Methodology
(3) Bode, Lipshutz, Little, Pettus
Prerequisite: advancement to candidacy. Lecture, 3 hours.
Primarily intended for graduate students in the organic division.
The design, development, presentation, and organization of new concepts for organic synthesis and methodologies is an essential skill for graduate students. Course focuses on advances in these areas and developng skills for writing and presenting research proposals. (W,S)
258. Mechanisms of Organic and Enzymatic Reactions
(3) Staff
Prerequisite: consent of instructor. Lecture, 3 hours.
Formal presentation of seminars on recent literature dealing with mechanisms of organic and enzymatic reactions accompanied by open discussion of the topics considered.
259. Selected Topics in Biological Chemistry
(1-4) Staff
Prerequisite: consent of instructor.
Same course as BMB 259. Course may be repeated with a different topic (18 units maximum). Lecture, 1 to 4 hours.
Selected topics from bio-organic, biophysical, or biological chemistry. The contents of this course will vary.
261. Enzyme Mechanisms
(3) Parsons, Reich
Prerequisites: Chemistry 142A-B-C or MCDB
108A-B-C. Lecture, 3 hours.
Chemistry, structure, and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.
262A. Drug Design
(3) Kahn, Reich
Lecture, 3 hours.
Sources for new drugs. Biochemistry of diseases. Target validation techniques. Mechanism of action of enzymes and receptors. Enzyme inhibition and receptor binding studies. Structure based drug design: conformational analysis, docking and binding affinity calculations. Course also teaches proposal writing skills.
262B. Drug Design
(3) Kahn, Reich
Lecture, 3 hours.
Medicinal chemistry for lead optimization, combinatorial synthesis, quantitative structure-activity relationships, pharmacokinetics, drug metabolism and toxicity, pharmacogenomics. Drugs that interact with DNA and protein drugs. Clinical trials, intellectual property in drug design. Students develop their own drug design project.
263. Arrow Pushing in Organic Chemistry
(2) Staff
Prerequisite: graduate standing.
Recommended preparation: a previous or current course in one of the following; Chemistry 227, 228, 229 or 233.
Covers the arrow pushing fomulasism and addresses molecular rearrangements and other organic reactions from this perspective.
267. Transition Metal Oxides
(3) Cheetham
Same course as Materials 203. Lecture, 3 hours.
Introduction to transition metal oxides. Ligand field theory. Structural basis of magnetism.
268A. Advanced Inorganic Chemistry
(3) Ford, Stucky
Prerequisite: consent of the chemistry graduate advisor.
Not open for credit to students who have completed Chemistry 173A, or 272A. Lecture, 3 hours.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.
268B. Advanced Inorganic Chemistry
(3) Ford, Stucky
Prerequisite: consent of the chemistry graduate advisor.
Not open for credit to students who have completed Chemistry 173B, or 272B. Lecture, 3 hours.
Structures of ordered crystalline solids, x-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.
270. Graduate Seminar in Inorganic/Analytical Chemistry
(2) Staff
Prerequisite: graduate standing. Seminar, 2 hours.
Seminars on current research topics in Inorganic/Analytical Chemistry presented by faculty, visiting scholars, and postdoctoral and senior graduate students.
271. Bioinorganic Chemistry
(3) Butler
Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Selected topics in bioinorganic chemistry and metallobiochemistry with a major focus on recent developments. Topics will include discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopic properties of metal sites.
272. Reaction Mechanisms in Organometallic and Inorganic Chemistry
(3) Butler, Ford
Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Discussion of chemical reaction mechanisms. Emphasis will be on fundamental reactions of metal compounds such as substitution, addition, elimination, and redox reactions for homogenous catalysis mechanisms and other complex systems.
273. Structural Inorganic Chemistry
(3) Cheetham, Stucky
Prerequisites: Chemistry 173A-B and 175. Lecture, 3 hours.
The use of x-ray and neuron scattering to characterize solid state materials. Subjects include the crystal unit cell, space groups, structure determination and refinement. It is recommended that the student have an elementary introduction to vectors, matrices, and Fourier series.
274. Solid State Inorganic/Materials
(3) Cheetham, Stucky
Prerequisites: Chemistry 173A-B.
Same course as Materials 274. Lecture, 3 hours.
An introductory course describing the synthesis, physical characterization, structure, electronic properties, and uses of solid state materials. (Normally offered in alternate years.)
275. Physical - Inorganic Chemistry
(3) Ford
Prerequisite: consent of the chemistry graduate advisor. Lecture, 3 hours.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.
276. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) Ford
Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.
279. Selected Topics in Inorganic Chemistry
(1-4) Staff
Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 3 hours.
This course is designed to reflect recent developments in inorganic chemistry.
284. Chemical Literature
(2) Huber
Prerequisite: consent of the chemistry graduate advisor only. Lecture, 3 hours.
Lectures and exercises on the literature and other information resources of use in chemistry. (W)
290. Seminar in Chemistry and Biochemistry
(2) Staff
Prerequisite: consent of instructor.
May be repeated for credit. Lecture, 1 hour.
Presentation of seminar required of all chemistry graduate students. (F,W,S)
293. Faculty Research Seminar
(2) Staff
Prerequisite: consent of instructor. Seminar, 2 hours.
A series of seminars by departmental faculty describing their active research projects. (F)
501A. Techniques of Teaching and Laboratory Class Supervision
(2) Van Koppen
Prerequisite: graduate standing.
S/U grade. Discussion, 1 hour.
An initial 2-3 day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants. (F)
594. Special Topics
(1-4) Staff
Variable hours.
Special seminar on research subjects of current interest.
595. Group Studies
(2) Aue, Bode, Lipshutz, Little, Pettus
Critical review of research in selected fields. Regular meetings are held in which the student presents for discussion information from the recent chemical literature.
596. Directed Reading and Research
(2-12) Staff
Same course as Biochemistry-Molecular Biology 596CH. No more than half the units necessary for the master’s degree may be taken in Chemistry 596. Tutorial, 2-8 hours.
Individual tutorial. Instructor usually the student’s major professor. A written proposal for each tutorial must be approved by the department chair. Each faculty member has a unique number designation.
597. Individual Study for Master’s Comprehensive Examinations and Ph.D. Examinations
(1-3) Staff
No unit credit allowed toward advanced degree(s). S/U grade. Variable hours.
Instructor should be the student’s major professor or chair of the doctoral committee.
598. Master’s Thesis Research and Preparation
(1-12) Staff
No unit credit allowed toward advanced degree. S/U grade. Variable hours.
Only for research underlying the thesis, writing the thesis. Instructor should be the chair of the student’s thesis committee.
599. Ph.D. Dissertation Research and Preparation
(1-12) Staff
S/U Grade. Variable hours.
Only for research underlying the dissertation, writing the dissertation. Instructor should be the chair of the student’s doctoral committee.
Related Courses in Other Departments
EEMB: 126MM, 226MM
MCDB: 108A-B-C, 109L, 123, 140L, 224
